UniProt MCP Server

What it does

Connects AI assistants to the UniProt protein database, enabling sophisticated protein research, comparative genomics, structural biology analysis, and systems biology investigations via the UniProt REST API.

Tools

• search_proteins: Search by name, keyword, or organism.
• get_protein_info: Retrieve detailed protein data by accession.
• search_by_gene: Find proteins using gene symbols.
• get_protein_sequence: Get amino acid sequences in FASTA/JSON.
• get_protein_features: Access functional domains and binding sites.
• compare_proteins: Side-by-side comparison of multiple proteins.
• get_protein_homologs: Discover homologous proteins across species.
• get_protein_structure: Access 3D structural data from PDB.
• get_protein_pathways: Integration with KEGG and Reactome pathways.

Installation

{
  "mcpServers": {
    "uniprot": {
      "command": "node",
      "args": ["/path/to/uniprot-server/build/index.js"],
      "env": {}
    }
  }
}

Supported hosts

• Claude Desktop