
Run DnaSP-style population genetics analyses (π, Tajima's D, LD, MK, Ka/Ks, SFS) on aligned sequences locally and produce TSV/Markdown reports.
DnaSP reimplements the DnaSP 6 analysis suite as a ClawBio skill: it constructs and runs population genetics analyses (polymorphism, neutrality tests, LD, recombination, divergence, MK, Ka/Ks, codon usage, SFS) from FASTA/NEXUS inputs and emits reproducible TSV and Markdown reports and figures. The heavy computation runs in the included Python scripts; the agent interprets results and explains their meaning.
Use this skill when you need population genetics summary statistics or tests on aligned sequence data — e.g. nucleotide diversity, Tajima's D, LD measures, recombination Rm, divergence (Dxy/Da), McDonald–Kreitman tests, Ka/Ks, or codon usage metrics. Not for phylogenetic tree building or VCF annotation.
Works with agents that can run local Python scripts and present tabular/figure outputs. The agent should not invent statistics — it must trust and explain dnasp.py outputs.
This skill has not been reviewed by our automated audit pipeline yet.
arXiv Search
Search arXiv for recent preprints and build local Markdown summaries; ideal for CS, math, physics, and quantitative-bio literature discovery.
Alternative Splicing Analysis Pipeline
End-to-end pipeline for short-read bulk RNA-seq alternative splicing analysis: QC, STAR 2-pass alignment, junction QC, rMATS differential splicing, isoform swit
PLINK Basics
Commands and examples for converting genotype formats and running standard QC filters (MAF, geno, mind, HWE) with PLINK 1.9/2.0.
AlphaFold Structure Query
Query the AlphaFold EBI API to fetch predicted protein structures, download PDB/CIF files, and inspect confidence metrics (pLDDT/PAE).
PyTorch Geometric (PyG) Guide
Authoritative guide for building and scaling Graph Neural Networks using PyTorch Geometric: data, layers, training patterns, and common pitfalls.