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from agent-almanac24
Design and optimize an HPLC method (RP, NP, IC, HILIC) including column selection, mobile phase, gradient, and detection for robust analytical separations.
Guides analysts through designing and validating HPLC methods for separating and quantifying non-volatile analytes. Covers chromatographic mode selection (RP, NP, IC, HILIC), column choice, mobile phase composition and pH control, gradient design, detector configuration (UV/DAD/MS), method verification, and validation checks.
Use when developing new analytical methods for QA/QC, transferring methods between instruments, optimizing selectivity, or converting to UHPLC. Applicable in pharmaceutical, chemical, and food testing labs.
Best used by lab-focused agents and code assistants that can format method SOPs and generate parameter tables for instruments (Lab automation, Copilot-style agents).
A detailed HPLC method development guide skill (Spanish locale) from the agent-almanac repo. No scripts included — pure reference knowledge in SKILL.md. Well-structured with 5 procedural steps, validation checklist, common errors, and failure-mode guidance. Only uses read-only allowed-tools. Very niche domain (analytical chromatography) limiting broad usefulness.
Clean skill, no security concerns. Part of a multilingual skill collection (agent-almanac). Well-written for its narrow domain but very specialized audience.
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